Neural stemness contributes to cell tumorigenicity

Abstract Background Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number reveal that cells share property and regulatory network with neural stem/progenitor cells. However, relationship between stemness cell tumorigenicity is unknown. Results We show cells, but not non-neural embryonic or somatic types, exhibit potential for differentiation into tissue types all germ layers when they are placed in non-native environment by transplantation immunodeficient nude mice. Likewise, capable tumor initiation have because their abilities neurosphere formation stem cell-specific serum-free medium potential, addition to neuronal was characterized previously. Moreover, loss pro-differentiation factor myoblasts, which no tumorigenicity, lead myoblast identity, gain stemness, re-differentiation. By contrast, via results tumorigenicity. These suggest contributes phenotypic heterogeneity might be an effect stemness. Bioinformatic analysis reveals genes general correlated development cancer, role development; whereas not. Most specific emerged typical species representing transition from unicellularity multicellularity during evolution. Genes Monosiga brevicollis , unicellular closest known relative metazoans, biased toward Conclusions source This due state ground hence type diversification evolution, tumorigenesis process restoration along default route pre-determined evolutionary advantage state.